Heparin-binding growth-associated molecule (HB-GAM) in activity-dependent neuronal plasticity in hippocampus
نویسنده
چکیده
Academic Dissertation To be presented for public criticism, with the permission of the Role of heparin-binding growth-associated molecule (HB-GAM) in hippocampal LTP and spatial learning revealed by studies on overexpressing and knockout mice. Syndecan-3-deficient mice exhibit enhanced LTP and impaired hippocampus-dependent memory. Mol Rauvala H. The two thrombospondin type I repeat domains of heparin-binding growth-associated molecule are necessary and sufficient for the interaction with hippocampal neurons.
منابع مشابه
Heparin-binding growth-associated molecule contains two heparin-binding beta -sheet domains that are homologous to the thrombospondin type I repeat.
Heparin-binding growth-associated molecule (HB-GAM) is an extracellular matrix-associated protein implicated in the development and plasticity of neuronal connections of brain. Binding to cell surface heparan sulfate is indispensable for the biological activity of HB-GAM. In the present paper we have studied the structure of recombinant HB-GAM using heteronuclear NMR. These studies show that HB...
متن کاملThe two thrombospondin type I repeat domains of HB-GAM display a cooperative function in N-syndecan binding and regulation of synaptic plasticity.
The TSR (thrombospondin type I repeat) is defined by a conserved tryptophan/cysteine motif and found in a large family of extracellular matrix and cell surface proteins (for review, see [1]). These proteins include thrombospondins 1 and 2, F-spondin, mindin, and semaphorins F and G. HB-GAM (heparin-binding growth-associated molecule, also designated as pleiotrophin) and MK (midgestation-kidney ...
متن کاملIsolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3).
HB-GAM (heparin binding growth-associated molecule; pleiotrophin) is a secretory, extracellular matrix-associated protein that is strongly expressed in developing nervous tissues and belongs to a novel family of differentiation/growth factors. It promotes axonal growth from perinatal rat brain neurons and is suggested to be mitogenic for some cell types and to display cell-transforming activity...
متن کاملInteraction of soluble and surface-bound heparin binding growth-associated molecule with heparin.
The interaction of heparin with heparin binding growth-associated molecule (HB-GAM) was studied using isothermal titration calorimetry (ITC) and surface plasmon resonance (SPR). ITC studies showed that, in solution, heparin bound HB-GAM with a deltaH of -30 kcal/mole corresponding to a dissociation constant (Kd) of 460 nM. The stoichiometry of interaction was 3 moles of HB-GAM per mole of hepar...
متن کاملHG-GAM KNOCK-OUTS 1 Running head: HB-GAM KNOCK-OUTS Neuroanatomical Characteristics of Mice Deficient in Heparin Binding Growth Associated Molecule (HB-GAM)
Pervasive Developmental Disorder (PDD) is a categorical term used to classify disorders in which the patient suffers deficits in three main domains: language, behavior and social skills. Heparin Binding Growth Associated Molecule (HB-GAM) is an extracellular protein involved in neurite outgrowth and radial migration. Mice deficient in HB-GAM demonstrate deficits in cognition, behavior and socia...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2005